Epigenetics is the study of changes in gene function that can be inherited but do not involve alterations to the DNA sequence. At its core, epigenetics investigates the mechanisms that regulate gene expression without changing the underlying DNA sequence. Nuclear signaling refers to signaling pathways within the cell nucleus that are triggered by transcription factors to initiate specific gene expression programs, thereby controlling cellular functions and behaviors.

Research in epigenetics and nuclear signaling spans a broad spectrum from basic science to clinical applications, aiming to deepen the understanding of gene expression regulation, the dynamic processes of nuclear signaling, and their roles in diseases. Key research areas include the regulation of chromatin structure, epigenetic modifications (such as methylation, acetylation, and phosphorylation), the molecular mechanisms of nuclear signaling pathways, the dynamic regulation of gene expression, and their roles in development, disease, and environmental adaptation.